Coregulation of Class Ia and Ontogeny: High Expression in Epithelia and Expression of MHC Class Ia and Class Ib During
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The most severe endemia of our time, iodine deficiency affects more than one billion people worldwide. Two hundred Million cases of goiter and six million of creatinism have recorded worldwide. Iodine deficiency disorders (IDD) is the most health problem of our country. In a prospective study, the prevalence and clinical staging of endemic goiter in 16054 students (8262 male and 7792 fe...
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PROBLEM The regulatory mechanisms governing differential expression of classical major histocompatibility complex (MHC) class I (MHC-Ia) and non-classical MHC class I (MHC-Ib) genes are poorly understood. METHOD OF STUDY Quantitative reverse transcription- polymerase chain reaction (PCR) was used to compare the abundance of MHC-I transcripts and related transcription factors in peripheral blo...
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Preimplantation mouse embryos express both classical (class Ia) and nonclassical (class Ib) MHC class I proteins, and yet are not rejected by the maternal immune system. Although the function of the embryonic MHC class Ia proteins is unknown, one MHC class Ib protein, Qa-2, the product of the preimplantation embryo development (Ped) gene, actually enhances reproductive success. Similar in struc...
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Background: During pregnancy, the maternal immune system is in close contact with cells and tissue from the semiallogenic fetus .The Human Leucocyte Antigen (HLA) class Ib molecules, HLA-E, -F and -G, are expressed at the materno-fetal interface. Because of the apparent immunoregulatory functions of these proteins, they may be involved in successful acceptance of the semi-allogenic fetus during...
متن کاملAn MHC class Ib-restricted CD8+ T cell response to lymphocytic choriomeningitis virus.
Conventional MHC class Ia-restricted CD8(+) T cells play a dominant role in the host response to virus infections, but recent studies indicate that T cells with specificity for nonclassical MHC class Ib molecules may also participate in host defense. To investigate the potential role of class Ib molecules in anti-viral immune responses, K(b-/-)D(b-/-)CIITA(-/-) mice lacking expression of MHC cl...
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تاریخ انتشار 1998